Identifying Prodromal and Preclinical Markers for Predicting Diagnosis and Progression in Dementia

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Dr. Firuz Kamalov

Professor, Canadian University DubaiCanadian University Dubai

"The Dubai RDI program exemplifies Dubai’s commitment to advancing health and AI research on a global scale. Being part of this initiative is both an honor and an exciting opportunity. We are eager to contribute to the city's research ecosystem and showcase the exceptional talent driving innovation in Dubai."

This project, led by Canadian University Dubai, pioneers an Explainable Artificial Intelligence (AI) system aimed at the early detection of dementia and its potential progression, particularly prodromal Alzheimer’s disease (AD). By combining cognitive, neuropsychiatric, and biomarker data, the system identifies subtle changes associated with the earliest stages of dementia. It leverages an innovative Explainable AI algorithm, designed to provide transparent and human-interpretable insights that enhance clinical and patient trust.

Aligned with Dubai’s RDI Grant Program in Health and Life Sciences, the initiative underscores a commitment to advancing healthcare through cutting-edge technology. An international consortium of senior academics and researchers, each with extensive expertise in AI, cognitive neuroscience, and biomarker analysis, will collaborate to consolidate large-scale datasets—sourced in part from the Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Key deliverables include a diagnostic software platform that integrates machine learning models with new rule-based methods, accessible via a cloud-based service and intuitive web interface. The system’s robust design facilitates earlier detection of prodromal dementia, enabling timely interventions and management strategies. Beyond its technical achievements, the project aims to publish its findings in top tier journals and explore patent opportunities.

The expected impact is significant: earlier diagnosis can improve patient care, guide clinical decision-making, and offer vital support to families. By training and involving Emirati staff, the project also contributes to the UAE’s broader objective of empowering local talent in health technology. Overall, this research represents a major step toward transforming dementia care through AI-driven innovation.